A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

T-bet plays a crucial role in Th1 development. We investigated the role of T-bet in the development of allograft rejection in an established MHC class II–mismatched (bm12 into B6) model of chronic allograft vasculopathy (CAV). Intriguingly, and in contrast to IFN-γ(−/−) mice that are protected from...

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Detalhes bibliográficos
Main Authors: Yuan, Xueli, Paez-Cortez, Jesus, Schmitt-Knosalla, Isabela, D'Addio, Francesca, Mfarrej, Bechara, Donnarumma, Michela, Habicht, Antje, Clarkson, Michael R., Iacomini, John, Glimcher, Laurie H., Sayegh, Mohamed H., Ansari, M. Javeed
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605226/
https://ncbi.nlm.nih.gov/pubmed/19047438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081937
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