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T-cell exhaustion in allograft rejection and tolerance

PURPOSE OF REVIEW: The role of T-cell exhaustion in the failure of clearance of viral infections and tumors is well established. There are several ongoing trials to reverse T-cell exhaustion for treatment of chronic viral infections and tumors. The mechanisms leading to T-cell exhaustion and its rol...

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Publicado en:Curr Opin Organ Transplant
Main Authors: Thorp, Edward B., Stehlik, Christian, Ansari, M. Javeed
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351043/
https://ncbi.nlm.nih.gov/pubmed/25563990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MOT.0000000000000153
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