4-Aminobiphenyl Downregulation of NAT2 Acetylator Genotype–Dependent N- and O-acetylation of Aromatic and Heterocyclic Amine Carcinogens in Primary Mammary Epithelial Cell Cultures from Rapid and Slow Acetylator Rats

Aromatic and heterocyclic amine carcinogens present in the diet and in cigarette smoke induce breast tumors in rats. N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) enzymes have important roles in their metabolic activation and deactivation. Human epidemiological studies suggest that g...

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Autors principals: Jefferson, Felicia A., Xiao, Gong H., Hein, David W.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2009
Matèries:
Systems Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605175/
https://ncbi.nlm.nih.gov/pubmed/18842621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn216
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