High frequency of loss of heterozygosity at 11p15 and IGF2 overexpression is not associated with clinical outcome in childhood adrenocortical tumors positive for the R337H TP53 mutation

A germline TP53 R337H mutation is present in childhood adrenocortical tumors (ACT) from southern Brazil. Other genetic alterations are also frequently found in these tumors. This study was designed to assess whether alterations of the 11p15 region exist in childhood ACT, accounting for IGF2 overexpr...

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Hoofdauteurs: Rosati, Roberto, Cerrato, Flavia, Doghman, Mabrouka, Pianovski, Mara A.D., Parise, Guilherme A., Custódio, Gislaine, Zambetti, Gerard P., Ribeiro, Raul C., Riccio, Andrea, Figueiredo, Bonald C., Lalli, Enzo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603647/
https://ncbi.nlm.nih.gov/pubmed/18786438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergencyto.2008.05.010
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