An unusual allosteric mobility of the C-terminal helix of a high affinity α(L) integrin I domain variant bound to ICAM-5

Integrins are cell surface receptors that transduce signals bi-directionally across the plasma membrane. The key event of integrin signaling is the allosteric regulation between its ligand-binding site and the C-terminal helix (α7) of intergin’s inserted (I) domain. A significant axial movement of t...

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Main Authors: Zhang, Hongmin, Casasnovas, Jose M., Jin, Moonsoo, Liu, Jin-huan, Gahmberg, Carl G., Springer, Timothy A., Wang, Jia-huai
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603608/
https://ncbi.nlm.nih.gov/pubmed/18691975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.06.022
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