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An unusual allosteric mobility of the C-terminal helix of a high affinity α(L) integrin I domain variant bound to ICAM-5
Integrins are cell surface receptors that transduce signals bi-directionally across the plasma membrane. The key event of integrin signaling is the allosteric regulation between its ligand-binding site and the C-terminal helix (α7) of intergin’s inserted (I) domain. A significant axial movement of t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2603608/ https://ncbi.nlm.nih.gov/pubmed/18691975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.06.022 |
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