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Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response
The damaging effects of hypertonic stress on cellular proteins are poorly defined, and almost nothing is known about the pathways that detect and repair hypertonicity-induced protein damage. To begin addressing these problems, we screened ∼19,000 Caenorhabditis elegans genes by RNA interference (RNA...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2603564/ https://ncbi.nlm.nih.gov/pubmed/18829898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00450.2008 |
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