Hyperinsulinemia fails to augment ET-1 action in the skeletal muscle vascular bed in vivo in humans

Endogenous endothelin action is augmented in human obesity and type 2 diabetes and contributes to endothelial dysfunction and impairs insulin-mediated vasodilation in humans. We hypothesized that insulin resistance-associated hyperinsulinemia could preferentially drive endothelin-mediated vasoconstr...

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Autores principales: Lteif, Amale A., Fulford, Angie D., Considine, Robert V., Gelfand, Inessa, Baron, Alain D., Mather, Kieren J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2008
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603554/
https://ncbi.nlm.nih.gov/pubmed/18957616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.90549.2008
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