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Hyperinsulinemia fails to augment ET-1 action in the skeletal muscle vascular bed in vivo in humans
Endogenous endothelin action is augmented in human obesity and type 2 diabetes and contributes to endothelial dysfunction and impairs insulin-mediated vasodilation in humans. We hypothesized that insulin resistance-associated hyperinsulinemia could preferentially drive endothelin-mediated vasoconstr...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2603554/ https://ncbi.nlm.nih.gov/pubmed/18957616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.90549.2008 |
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