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Spinal and Bulbar Muscular Atrophy: A motoneuron or muscle disease?
Kennedy Disease (KD, or spinal and bulbar muscular atrophy) is caused by a CAG/polyglutamine expansion in the androgen receptor (AR) gene. Both motoneurons and muscles are affected by KD, but where mutant ARs act to initiate this disease is not clear. We discuss recent insights into this disease wit...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2603477/ https://ncbi.nlm.nih.gov/pubmed/18775514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2008.08.006 |
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