Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy()

Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease caused by an abnormal expansion of a tandem CAG repeat in exon 1 of the androgen receptor (AR) gene that results in an abnormally long polyglutamine tract (polyQ) in the AR protein. As a result, the mutant AR (ARpolyQ) misfo...

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Main Authors: Rusmini, Paola, Crippa, Valeria, Giorgetti, Elisa, Boncoraglio, Alessandra, Cristofani, Riccardo, Carra, Serena, Poletti, Angelo
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2013
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748343/
https://ncbi.nlm.nih.gov/pubmed/23810450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.05.026
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