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Kinetic Isotope Effects on Aromatic and Benzylic Hydroxylation by Chromobacterium Violaceum Phenylalanine Hydroxylase as Probes of the Chemical Mechanism and Reactivity

Phenylalanine hydroxylase from Chromobacterium violaceum (CvPheH) is a non-heme iron monooxygenase that catalyzes the hydroxylation of phenylalanine to tyrosine. In the present study we used deuterium kinetic isotope effects to probe the chemical mechanisms of aromatic and benzylic hydroxylation in...

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書誌詳細
主要な著者: Panay, Aram J., Fitzpatrick, Paul F.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603180/
https://ncbi.nlm.nih.gov/pubmed/18817418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801295w
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