DNA Sequence Context as a Determinant of the Quantity and Chemistry of Guanine Oxidation Produced by Hydroxyl Radicals and One-electron Oxidants

DNA sequence context has emerged as a critical determinant of the location and quantity of nucleobase damage caused by many oxidizing agents. However, the complexity of nucleobase and 2-deoxyribose damage caused by strong oxidants such as ionizing radiation and the Fenton chemistry of Fe(2+)-EDTA/H(...

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Detalhes bibliográficos
Main Authors: Margolin, Yelena, Shafirovich, Vladimir, Geacintov, Nicholas E., DeMott, Michael S., Dedon, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602890/
https://ncbi.nlm.nih.gov/pubmed/18948263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806809200
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