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A rugged free energy landscape separates multiple functional RNA folds throughout denaturation

The dynamic mechanisms by which RNAs acquire biologically functional structures are of increasing importance to the rapidly expanding fields of RNA therapeutics and biotechnology. Large energy barriers separating misfolded and functional states arising from alternate base pairing are a well-apprecia...

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Detalhes bibliográficos
Main Authors: Ditzler, Mark A., Rueda, David, Mo, Jingjie, Håkansson, Kristina, Walter, Nils G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602785/
https://ncbi.nlm.nih.gov/pubmed/18988629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn871
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