A rugged free energy landscape separates multiple functional RNA folds throughout denaturation

The dynamic mechanisms by which RNAs acquire biologically functional structures are of increasing importance to the rapidly expanding fields of RNA therapeutics and biotechnology. Large energy barriers separating misfolded and functional states arising from alternate base pairing are a well-apprecia...

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Détails bibliographiques
Auteurs principaux: Ditzler, Mark A., Rueda, David, Mo, Jingjie, Håkansson, Kristina, Walter, Nils G.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2008
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602785/
https://ncbi.nlm.nih.gov/pubmed/18988629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn871
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