Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases

DNA aptamers RT5, RT6 and RT47 form a group of related sequences that inhibit HIV-1 reverse transcriptase (RT). The essential inhibitory structure is identified here as bimodular, with a 5′ stem–loop module physically connected to a 3′-guanosine quadruplex module. The stem–loop tolerates considerabl...

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Main Authors: Michalowski, Daniel, Chitima-Matsiga, Rebecca, Held, Daniel M., Burke, Donald H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602765/
https://ncbi.nlm.nih.gov/pubmed/18996899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn891
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