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Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers

Nucleic acid aptamers can potentially be developed as broad-spectrum antiviral agents. Single-stranded DNA (ssDNA) aptamer RT1t49 inhibits reverse transcriptases (RT) from HIV-1 and diverse lentiviral subtypes with low nanomolar values of Kd and IC(50). To dissect the structural requirements for inh...

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Bibliografski detalji
Glavni autori: Kissel, Jay D., Held, Daniel M., Hardy, Richard W., Burke, Donald H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976467/
https://ncbi.nlm.nih.gov/pubmed/17644816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm420
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