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A selective Gβγ-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol
The current understanding about ethanol effects on the ligand-gated ion channel (LGIC) superfamily has been restricted to identify potential binding sites within transmembrane (TM) domains in the Cys-loop family. Here, we demonstrate a key role of the TM3–4 intracellular loop and Gβγ signaling for p...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2602604/ https://ncbi.nlm.nih.gov/pubmed/19074265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806257105 |
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