DELETION OF THE PDZ MOTIF OF HPV16 E6 PREVENTING IMMORTALIZATION AND ANCHORAGE-INDEPENDENT GROWTH IN HUMAN TONSIL EPITHELIAL CELLS

BACKGROUND: Human papillomavirus 16 (HPV16) has been associated with head and neck squamous cell carcinoma (HNSCC) in up to 60%of sampled specimens. METHODS: To understand better the viral genes required to transform human tonsil epithelial cells (HTEC), we isolated HTECs and transduced them with re...

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Detalhes bibliográficos
Main Authors: Spanos, William C., Geiger, Jeremy, Anderson, Mary E., Harris, George F., Bossler, Aaron D., Smith, Russell B., Klingelhutz, Aloysius J., Lee, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600880/
https://ncbi.nlm.nih.gov/pubmed/17657785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hed.20673
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