Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

α-synuclein (α-syn) is a main component of Lewy bodies (LB) that occur in many neurodegenerative diseases, including Parkinson's disease (PD), dementia with LB (DLB) and multi-system atrophy. α-syn mutations or amplifications are responsible for a subset of autosomal dominant familial PD cases,...

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Hlavní autoři: Qiao, Liyan, Hamamichi, Shusei, Caldwell, Kim A, Caldwell, Guy A, Yacoubian, Talene A, Wilson, Scott, Xie, Zuo-Lei, Speake, Lisa D, Parks, Rachael, Crabtree, Donna, Liang, Qiuli, Crimmins, Stephen, Schneider, Lonnie, Uchiyama, Yasuo, Iwatsubo, Takeshi, Zhou, Yi, Peng, Lisheng, Lu, YouMing, Standaert, David G, Walls, Ken C, Shacka, John J, Roth, Kevin A, Zhang, Jianhua
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600785/
https://ncbi.nlm.nih.gov/pubmed/19021916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-1-17
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