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Path of Nascent Polypeptide in Exit Tunnel Revealed by Molecular Dynamics Simulation of Ribosome

Molecular dynamics simulations were carried out on Thermus thermophilus 70S ribosome with and without a nascent polypeptide inside the exit tunnel. Modeling of the polypeptide in the tunnel revealed two possible paths: one over Arg(92) of L22 and one under (from the viewpoint of 50S on top of 30S)....

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Bibliografiske detaljer
Main Authors: Ishida, Hisashi, Hayward, Steven
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599861/
https://ncbi.nlm.nih.gov/pubmed/18936244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.134890
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