Analysis of STAT1 Activation by Six FGFR3 Mutants Associated with Skeletal Dysplasia Undermines Dominant Role of STAT1 in FGFR3 Signaling in Cartilage

Activating mutations in FGFR3 tyrosine kinase cause several forms of human skeletal dysplasia. Although the mechanisms of FGFR3 action in cartilage are not completely understood, it is believed that the STAT1 transcription factor plays a central role in pathogenic FGFR3 signaling. Here, we analyzed...

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Detalhes bibliográficos
Main Authors: Krejci, Pavel, Salazar, Lisa, Kashiwada, Tamara A., Chlebova, Katarina, Salasova, Alena, Thompson, Leslie Michels, Bryja, Vitezslav, Kozubik, Alois, Wilcox, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597732/
https://ncbi.nlm.nih.gov/pubmed/19088846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003961
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