Synthesis and Characterization of New Piperazine-Type Inhibitors for Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)

The mode of action of Δlac-acetogenins, strong inhibitors of bovine heart mitochondrial complex I, is different from that of traditional inhibitors such as rotenone and piericidin A [Murai et al. (2007) Biochemistry 46, 6409−6416]. As further exploration of these unique inhibitors might provide new...

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Hlavní autoři: Ichimaru, Naoya, Murai, Masatoshi, Kakutani, Nobuyuki, Kako, Junko, Ishihara, Atsushi, Nakagawa, Yoshiaki, Nishioka, Takaaki, Yagi, Takao, Miyoshi, Hideto
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597681/
https://ncbi.nlm.nih.gov/pubmed/18781777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8010362
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