Inhibitors of a Na(+)-pumping NADH-ubiquinone oxidoreductase play multiple roles to block enzyme function

The Na(+)-pumping NADH-ubiquinone (UQ) oxidoreductase (Na(+)-NQR) is present in the respiratory chain of many pathogenic bacteria and is thought to be a promising antibiotic target. Whereas many details of Na(+)-NQR structure and function are known, the mechanisms of action of potent inhibitors is n...

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Vydáno v:J Biol Chem
Hlavní autoři: Masuya, Takahiro, Sano, Yuki, Tanaka, Hinako, Butler, Nicole L., Ito, Takeshi, Tosaki, Tatsuhiko, Morgan, Joel E., Murai, Masatoshi, Barquera, Blanca, Miyoshi, Hideto
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Bioenergetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476727/
https://ncbi.nlm.nih.gov/pubmed/32690607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014229
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