Mac-1 promotes FcγRIIA-dependent cell spreading and migration on immune complexes

The integrin Mac-1 plays a critical role in Fc receptor (FcR)-mediated antibody-dependent cellular cytotoxicity (ADCC). However, the mechanism by which Mac-1 facilitates the functions of FcγRIIA, a major FcR expressed on human leukocytes, is not fully understood. We report here that Mac-1 sustains c...

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Bibliographic Details
Main Authors: Xiong, Ying, Cao, Chunzhang, Makarova, Alexandra, Hyman, Brad, Zhang, Li
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597675/
https://ncbi.nlm.nih.gov/pubmed/16846215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060529u
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