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Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer
The ErbB2 receptor tyrosine kinase is overexpressed in ~ 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here we examine the role of the recently discovered ErbB negative regulator LRIG1 in ErbB2 (+) breast cancer. We observe that LRIG1 protein levels are s...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597648/ https://ncbi.nlm.nih.gov/pubmed/18922900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6316 |
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