Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer

The ErbB2 receptor tyrosine kinase is overexpressed in ~ 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here we examine the role of the recently discovered ErbB negative regulator LRIG1 in ErbB2 (+) breast cancer. We observe that LRIG1 protein levels are s...

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Autores principales: Miller, Jamie K., Shattuck, David L., Ingalla, Ellen Q., Yen, Lily, Borowsky, Alexander D., Young, Larry J.T., Cardiff, Robert D., Carraway, Kermit L., Sweeney, Colleen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597648/
https://ncbi.nlm.nih.gov/pubmed/18922900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6316
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