The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

Ca(2+) release-activated Ca(2+) (CRAC) channels underlie sustained Ca(2+) signaling in lymphocytes and numerous other cells following Ca(2+) liberation from the endoplasmic reticulum (ER). RNAi screening approaches identified two proteins, Stim1, 2 and Orai3-5, that together form the molecular basis...

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Main Authors: Penna, Aubin, Demuro, Angelo, Yeromin, Andriy V., Zhang, Shenyuan L., Safrina, Olga, Parker, Ian, Cahalan, Michael D.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597643/
https://ncbi.nlm.nih.gov/pubmed/18820677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07338
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