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Multidrug Resistance-Associated Protein 2 (Mrp2) is Primarily Responsible for the Biliary Excretion of Fexofenadine in Mice
Previous studies implicated P-glycoprotein (P-gp) as the major transport protein responsible for the biliary excretion of fexofenadine (FEX). However, FEX biliary excretion was not impaired in P-gp- or Bcrp-knockout mice, and Mrp2-deficient rats. The present study tested the hypothesis that species...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597637/ https://ncbi.nlm.nih.gov/pubmed/17913796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.107.017319 |
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