BCR-ABL fusion transcript types and levels and their interaction with secondary genetic changes in determining the phenotype of Philadelphia chromosome–positive leukemias

It remains unresolved how different BCR-ABL transcripts differentially drive lymphoid and myeloid proliferation in Philadelphia chromosome–positive (Ph(+)) leukemias. We compared BCR-ABL transcript type and level with kinase domain (KD) mutation status, genotype, and phenotype in 1855 Ph(+) leukemia...

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Detalhes bibliográficos
Main Authors: Jones, Dan, Luthra, Rajyalakshmi, Cortes, Jorge, Thomas, Deborah, O'Brien, Susan, Bueso-Ramos, Carlos, Hai, Seema, Ravandi, Farhad, de Lima, Marcos, Kantarjian, Hagop, Jorgensen, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597614/
https://ncbi.nlm.nih.gov/pubmed/18809762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-04-148791
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