Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach

Hematopoietic stem cells (HSCs) show pronounced heterogeneity in self-renewal and differentiation behavior, which is reflected in their repopulation kinetics. Here, a single-cell–based mathematical model of HSC organization is used to examine the basis of HSC heterogeneity. Our modeling results, whi...

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Dettagli Bibliografici
Autori principali: Roeder, Ingo, Horn, Katrin, Sieburg, Hans-Bernd, Cho, Rebecca, Muller-Sieburg, Christa, Loeffler, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597595/
https://ncbi.nlm.nih.gov/pubmed/18809760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-155374
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