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Enzymatic Synthesis of Lipid A Molecules with Four Amide-linked Acyl Chains: LpxA Acyltransferases Selective for an Analog of UDP-N-Acetylglucosamine in which an Amine Replaces the 3″-Hydroxyl Group
LpxA of Escherichia coli catalyzes the acylation of the glucosamine 3-OH group of UDP-GlcNAc, using R-3-hydroxymyristoyl-acyl carrier protein (ACP) as the donor substrate. We now demonstrate that LpxA in cell extracts of Mesorhizobium loti and Leptospira interrogans, which synthesize lipid A molecul...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597548/ https://ncbi.nlm.nih.gov/pubmed/15044493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M400597200 |
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