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Inhibitory activity restricts the function of an avian-like influenza polymerase in primate cells

Transmission of highly pathogenic avian influenza across species into human populations can result in lethal infections and increases the potential of a pandemic outbreak. A major determinant of species tropism is the influenza polymerase subunit PB2. We show here that a dominant inhibitory activity...

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Autores principales: Mehle, Andrew, Doudna, Jennifer A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597520/
https://ncbi.nlm.nih.gov/pubmed/18692771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.06.007
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