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Substitution of Wild-Type Yellow Fever Asibi Sequences for 17D Vaccine Sequences in ChimeriVax–Dengue 4 Does Not Enhance Infection of Aedes aegypti Mosquitoes

To address concerns that a flavivirus vaccine/wild-type recombinant virus might have a high mosquito infectivity phenotype, the yellow fever virus (YFV) 17D backbone of the ChimeriVax– dengue 4 virus was replaced with the corresponding gene sequences of the virulent YFV Asibi strain. Field-collected...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McGee, Charles E., Tsetsarkin, Konstantin, Vanlandingham, Dana L., McElroy, Kate L., Lang, Jean, Guy, Bruno, Decelle, Thierry, Higgs, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597369/
https://ncbi.nlm.nih.gov/pubmed/18266608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/527328
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