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Mutations in Fbx4 inhibit phosphorylation-dependent dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer
SCF(Fbx4) was recently identified as the E3 ligase for cyclin D1. We now describe cell cycle-dependent phosphorylation and dimerization of Fbx4 that is regulated by GSK3β and defective in human cancer. We present data demonstrating that a pathway involving Ras-Akt-GSK3β controls the temporal phospho...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597358/ https://ncbi.nlm.nih.gov/pubmed/18598945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.05.017 |
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