HITS-CLIP yields genome-wide insights into brain alternative RNA processing

Protein-RNA interactions play critical roles in all aspects of gene expression. Here we develop a genome-wide means of mapping protein-RNA binding sites in vivo, by high throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP). HITS-CLIP analysis of the neuron-specific s...

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Hauptverfasser: Licatalosi, Donny D., Mele, Aldo, Fak, John J., Ule, Jernej, Kayikci, Melis, Chi, Sung Wook, Clark, Tyson A., Schweitzer, Anthony C., Blume, John E., Wang, Xuning, Darnell, Jennifer C., Darnell, Robert B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597294/
https://ncbi.nlm.nih.gov/pubmed/18978773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07488
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