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A RAG1 mutation found in Omenn Syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction
Hypomorphic RAG mutants with severely reduced V(D)J recombination activity cause Omenn Syndrome (OS), an immunodeficiency with features of immune dysregulation and a restricted T cell receptor repertoire. Precisely how RAG mutants produce autoimmune and allergic symptoms has been unclear. Current mo...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597290/ https://ncbi.nlm.nih.gov/pubmed/18768869 |
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