Effects of levo- and dextrosimendan on NF-κB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli

BACKGROUND AND PURPOSE: Levosimendan is used in the treatment of decompensated heart failure. It increases the contractility of the myocardium by sensitizing troponin C to calcium. In addition, levosimendan has been reported to have beneficial effects in experimental models of septic shock. Because...

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Detalhes bibliográficos
Main Authors: Sareila, O, Korhonen, R, Auvinen, H, Hämäläinen, M, Kankaanranta, H, Nissinen, E, Moilanen, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597247/
https://ncbi.nlm.nih.gov/pubmed/19002103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.328
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