Inhibition of classical PKC isoenzymes downregulates STAT1 activation and iNOS expression in LPS-treated murine J774 macrophages

1. Proinflammatory cytokines and bacterial products trigger inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in inflammatory and tissue cells. In inflammation, NO acts as an important mediator having both proinflammatory and destructive effects. 2. Protein kinase C...

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Bibliographic Details
Main Authors: Salonen, Tiina, Sareila, Outi, Jalonen, Ulla, Kankaanranta, Hannu, Tuominen, Raimo, Moilanen, Eeva
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2006
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751509/
https://ncbi.nlm.nih.gov/pubmed/16432499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706672
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