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The effector T cells of diabetic subjects are resistant to regulation via CD4+FOXP3+ Treg

Defects in immune regulation have been implicated in the pathogenesis of diabetes in mouse and in man. In vitro assays using autologous regulatory (Treg) and responder (Teff) T cells have shown that suppression is impaired in diabetic subjects(1). In this study we addressed whether the source of thi...

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Autori principali: Schneider, Anya, Rieck, Mary, Sanda, Srinath, Pihoker, Catherine, Greenbaum, Carla, Buckner, Jane H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597079/
https://ncbi.nlm.nih.gov/pubmed/18981158
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