Toxoid of Pseudomonas aeruginosa exotoxin A generated by deletion of an active-site residue.

Glutamic acid-553 of Pseudomonas aeruginosa exotoxin A (ETA), identified previously as an active-site residue, was deleted by oligonucleotide-directed mutagenesis of the cloned toxin gene in Escherichia coli. The purified mutant toxin was stable, fully immunoreactive, and capable of blocking toxin r...

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Bibliografiske detaljer
Udgivet i:Infect Immun
Main Authors: Lukac, M, Pier, G B, Collier, R J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC259707/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2460407/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.56.12.3095-3098.1988
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