Essential Phosphatases and a Phospho-Degron Are Critical for Regulation of SRC-3/AIB1 Coactivator Function and Turnover

SRC-3/AIB1 is a master growth coactivator and oncogene, and phosphorylation activates it into a powerful coregulator. Dephosphorylation is a potential regulatory mechanism for SRC-3 function but the identity of such phosphatases remains unexplored. Herein, we report that using functional genomic scr...

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Autores principales: Li, Chao, Liang, Yao-Yun, Feng, Xin-Hua, Tsai, Sophia Y., Tsai, Ming-Jer, O’Malley, Bert W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597059/
https://ncbi.nlm.nih.gov/pubmed/18922467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.07.019
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