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Determinants for association and gRNA-directed endonuclease cleavage by purified RNA editing complexes from Trypanosoma brucei
U-insertion/deletion RNA editing in the single mitochondrion of ancient kinetoplastids is a unique mRNA maturation process needed for translation. Multi-subunit editing complexes recognize many pre-mRNA sites and modify them via cycles of three catalytic steps: guide-RNA (gRNA) mediated cleavage, in...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596986/ https://ncbi.nlm.nih.gov/pubmed/18572190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.003 |
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