Determinants for association and gRNA-directed endonuclease cleavage by purified RNA editing complexes from Trypanosoma brucei

U-insertion/deletion RNA editing in the single mitochondrion of ancient kinetoplastids is a unique mRNA maturation process needed for translation. Multi-subunit editing complexes recognize many pre-mRNA sites and modify them via cycles of three catalytic steps: guide-RNA (gRNA) mediated cleavage, in...

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Autores principales: Hernandez, Alfredo, Panigrahi, Aswini, Cifuentes-Rojas, Catherine, Sacharidou, Anastasia, Stuart, Kenneth, Cruz-Reyes, Jorge
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596986/
https://ncbi.nlm.nih.gov/pubmed/18572190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.003
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