TdT is required for the establishment of private virus-specific CD8(+) TCR repertoires and facilitates optimal CTL responses

Virus-immune CD8(+) TCR repertoires specific for particular peptide-MHC class I complexes may be substantially shared between (public), or unique to, individuals (private). Since public TCRs can show reduced terminal deoxynucleotidyl transferase (TdT)-mediated N-region additions, we analysed how TdT...

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Hauptverfasser: Kedzierska, Katherine, Thomas, Paul G., Venturi, Vanessa, Davenport, Miles P., Doherty, Peter C., Turner, Stephen J., La Gruta, Nicole L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596983/
https://ncbi.nlm.nih.gov/pubmed/18684946
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