CYP2D6 and HOXB13/IL17BR: Combining inherited and tumor gene markers for prediction of tamoxifen resistance

PURPOSE: Genetic variation in Cytochrome P450 2D6 (CYP2D6) and the gene expression ratio of the homeobox 13 (HOXB13) to interleukin-17B receptor (IL-17BR) are associated with tamoxifen resistance. We sought to determine the combined effect of inherited (CYP2D6) and somatic (HOXB13/IL17BR) gene varia...

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Detalhes bibliográficos
Main Authors: Goetz, Matthew P., Suman, Vera J., Couch, Fergus J., Ames, Matthew M., Rae, James M., Erlander, Mark G., Ma, Xiao-Jun, Sgroi, Dennis C., Reynolds, Carol A., Lingle, Wilma L., Weinshilboum, Richard M., Flockhart, David A., Desta, Zeruesenay, Perez, Edith A., Ingle, James N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596658/
https://ncbi.nlm.nih.gov/pubmed/18794098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0619
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