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A Conformational Switch to β-sheet Structure in Cytochrome c Leads to Heme Exposure; Implications for Cardiolipin Peroxidation and Apoptosis
Ultraviolet resonance Raman spectroscopy reveals that, when heated at pH 3, a substantial fraction (30 %) of cytochrome c converts to a β-sheet structure, at the expense of turns and helices. β-sheet formation is rapid, exhibiting a 2 µs rise time, following a temperature jump. It is proposed that a...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2007
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596592/ https://ncbi.nlm.nih.gov/pubmed/17227009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0678727 |
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