Ziram Causes Dopaminergic Cell Damage by Inhibiting E1 Ligase of the Proteasome

The etiology of Parkinson disease (PD) is unclear but may involve environmental toxins such as pesticides leading to dysfunction of the ubiquitin proteasome system (UPS). Here, we measured the relative toxicity of ziram (a UPS inhibitor) and analogs to dopaminergic neurons and examined the mechanism...

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Detalhes bibliográficos
Main Authors: Chou, Arthur P., Maidment, Nigel, Klintenberg, Rebecka, Casida, John E., Li, Sharon, Fitzmaurice, Arthur G., Fernagut, Pierre-Olivier, Mortazavi, Farzad, Chesselet, Marie-Francoise, Bronstein, Jeff M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596383/
https://ncbi.nlm.nih.gov/pubmed/18818210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802210200
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