The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP

The primary bile acid receptor farnesoid X receptor (FXR) maintains lipid and glucose homeostasis by regulating expression of numerous bile acid-responsive genes, including an orphan nuclear receptor and metabolic regulator SHP. Using SHP as a model gene, we studied how FXR activity is regulated by...

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Bibliographische Detailangaben
Hauptverfasser: Fang, Sungsoon, Tsang, Stephanie, Jones, Ryan, Ponugoti, Bhaskar, Yoon, Hyeryoung, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Willson, Timothy M., Kemper, Jongsook Kim
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Transcription, Chromatin, and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596376/
https://ncbi.nlm.nih.gov/pubmed/18842595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803531200
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