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Receptor-linked degradation of 125I-insulin is mediated by internalization in isolated rat hepatocytes.

When hepatocytes were freshly isolated from rat liver and incubated for various periods of time at 37 degrees C, the media from the incubation, when completely separated from the cells, actively degraded 125I-insulin. THis soluble protease activity was strongly inhibited by bacitracin but was unaffe...

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Bibliographic Details
Main Authors: Gorden, P., Freychet, P., Carpentier, J. L., Canivet, B., Orci, L.
Format: Artigo
Language:Inglês
Published: Yale Journal of Biology and Medicine 1982
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596013/
https://ncbi.nlm.nih.gov/pubmed/6753361
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