The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate

Dihydrodipicolinate synthase (DHDPS) mediates the key first reaction common to the biosynthesis of (S)-lysine and meso-diaminopimelate, molecules which play a crucial cross-linking role in bacterial cell walls. An effective inhibitor of DHDPS would represent a useful antibacterial agent; despite ext...

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Bibliografiska uppgifter
Huvudupphovsmän: Devenish, Sean R. A., Gerrard, Juliet A., Jameson, Geoffrey B., Dobson, Renwick C. J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2008
Ämnen:
Protein Structure Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593713/
https://ncbi.nlm.nih.gov/pubmed/19052357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108033654
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